Meet your future colleagues and interact with students from UC Davis and Western University as they explain, discuss, and answer questions about their research. The posters will be on display in the Vet Expo throughout the conference. Students will be available to discuss their theses during the lunch breaks on Saturday, June 22 and Sunday, June 23. They will also be presenting in the Vet Expo during the afternoon break.
Saturday, June 22, 12:10 PM-2:00 PM, 2:50 PM-3:30 PM
Sunday, June 23, 12:10 PM-2:00 PM
UC Davis Student Poster Presentations in the Vet Expo:
Christina Chang, Class of 2021
Ms. Chang is a third-year veterinary student at the UC Davis School of Veterinary Medicine, class of 2021. She was born and raised in Southern California. Her interest is in small animal medicine with a specialization in neurology.
Novel Animal Model of Maternal Autoantibody Related (MAR) Autism
Our preclinical model investigates one potential cause of autism spectrum disorder (ASD)—maternal autoantibodies targeting fetal brain tissue found in a subset of mothers of children with ASD. We hypothesize that these maternal antibodies cross the placenta during pregnancy and interact with fetal brain proteins important for neural development, resulting in long lasting changes in offspring brain and behavior. In this model, rat pups are continuously exposed to maternal antibodies throughout gestation. We predict that rat pups exposed to these antibodies prenatally will show deficits in social behavior as paralleled in children with ASD. Furthermore, we investigate expression of parvalbumin cells in the amygdala of the brain and its role in species typical social behavior. An emerging theory is that individuals with ASD perceive social interactions as threatening and therefore, avoid socialization as a means to alleviate the fear that it triggers.
Stephanie Feutsch, Class of 2021
Ms. Fuetsch is an incoming third-year veterinary student at the UC Davis School of Veterinary Medicine (class of 2021). She is interested in anatomic pathology and laboratory animal medicine. Ms. Fuetsch completed a BS and then earned an MS in biology from the University of Nevada-Reno with a focus on the movement of wild animals.
Meloxicam Sustained Release (MSR) Injection Site Reactions in Male and Female Mice
Meloxicam sustained release (MSR) is a compounded drug that may provide up to 72 hours of analgesia compared to 12 hours by the standard formulation. However, lesion development in animals following treatment with MSR has been reported in different species and was also observed in mice and rats in the UC Davis Mouse Biology Program. Our study evaluated injection site reactions in three commonly used research strains of mice; ICR(CD1), C57BL/6J, and Balb/cJ. Mice were injected with a single dose of MSR, or with a control dose of saline or standard meloxicam, and then observed for seven or 14-day time courses. Preliminary data assessment indicates that MSR-treated mice of all three strains, developed lesions with greater severity and duration than saline or meloxicam, and that the ICR(CD1) strain had more severe injection site reactions than the Balb/cJ and C57BL/6J strains.
Maegha Singh, Class of 2021
Ms. Singh is a member of the class of 2021 at UC Davis School of Veterinary Medicine. Originally, from the east coast, she grew up in Massachusetts and received my B.S. in chemistry from Carnegie Mellon University. She is interested in the intersection of veterinary medicine, bioengineering, and clinical research and wants to use her veterinary background to improve healthcare for both animals and people. She enjoys both companion animal and equine medicine.
Detecting Early Cartilage Degradation by Magic Angle Spinning Nuclear Magnetic Resonance (MAS NMR) Spectroscopy in a Mechanical Injury Model
Osteoarthritis (OA) is a common degenerative joint disease. It is currently detected by radiography or magnetic resonance imaging (MRI), but pathological changes are not detectable until later stages of the disease using these methods. The aim of this study was to detect biochemical changes seen in early stage cartilage degradation by measuring NMR spectral peaks in mechanically injured cartilage explants compared to uninjured and enzymatically digested cartilage. A bovine ex vivo mechanical model was used to simulate early cartilage injury. Biochemical differences between experimental groups were measured by MAS NMR and correlated with data from biochemical and mechanical testing of the cartilage samples.